Gefitinib
Product: Celgosivir (hydrochloride)
Identifier : DBSNPE000138
Drug : DB00317 (Gefitinib)
Interacting Gene/Enzyme : ATP-binding cassette sub-family G member 2
Gene Name : ABCG2
UniProt ID : Q9UNQ0
Allele Name : Not Available
Genotype(s) : (A;C)
Type(s) : ADR Directly Studied
Groups : Not Available
Description : In non-small lung cancer patients, those that are heterozygous (ABCG2 421C>A) have a higher risk of diarrhea.
References :
- Cusatis G, Gregorc V, Li J, Spreafico A, Ingersoll RG, Verweij J, Ludovini V, Villa E, Hidalgo M, Sparreboom A, Baker SD: Pharmacogenetics of ABCG2 and adverse reactions to gefitinib. J Natl Cancer Inst. 2006 Dec 6;98(23):1739-42. [PubMed:17148776 ]
PMID: 20631885
Gefitinib
Product: Saroglitazar (Magnesium)
Identifier : DBSNPE000163
Drug : DB00317 (Gefitinib)
Interacting Gene/Enzyme : Epidermal growth factor receptor
Gene Name : EGFR
UniProt ID : P00533
Allele Name : L858R
Genotype(s) : (G;G) / (G;T)
Type(s) : Effect Directly Studied
Groups : Not Available
Description : Associated with enhanced activation of the EGFR tyrosine kinase in patients with non-small cell lung cancer (NSCLC) recieving tyrosine kinase inhibitor therapy.
References :
- Lynch TJ, Bell DW, Sordella R, Gurubhagavatula S, Okimoto RA, Brannigan BW, Harris PL, Haserlat SM, Supko JG, Haluska FG, Louis DN, Christiani DC, Settleman J, Haber DA: Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med. 2004 May 20;350(21):2129-39. Epub 2004 Apr 29. [PubMed:15118073 ]
PMID: 25548285
Gefitinib
Product: Bay 41-4109 (racemate)
Identifier : DBSNPE000199
Drug : DB00317 (Gefitinib)
Interacting Gene/Enzyme : Epidermal growth factor receptor
Gene Name : EGFR
UniProt ID : P00533
Defining Change(s) :
- G > A or C or T (rs28929495 )
Allele Name : G719A/C
Genotype(s) : (T;T) / (G;T) / (A;A) / (A;G) / (C;C) / (C;G)
Type(s) : Effect Directly Studied
Groups : Not Available
Description : Associated with enhanced activation of the EGFR tyrosine kinase in patients with non-small cell lung cancer (NSCLC) recieving tyrosine kinase inhibitor therapy.
References :
- Lynch TJ, Bell DW, Sordella R, Gurubhagavatula S, Okimoto RA, Brannigan BW, Harris PL, Haserlat SM, Supko JG, Haluska FG, Louis DN, Christiani DC, Settleman J, Haber DA: Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med. 2004 May 20;350(21):2129-39. Epub 2004 Apr 29. [PubMed:15118073 ]
PMID: 21949864
Gefitinib
Product: Mutagenic Impurity of Tenofovir Disoproxil
Identifier : DBSNPE000204
Drug : DB00317 (Gefitinib)
Interacting Gene/Enzyme : Epidermal growth factor receptor
Gene Name : EGFR
UniProt ID : P00533
Defining Change(s) :
- T > A or G (rs121913444 )
Allele Name : L861Q
Genotype(s) : (A;A) / (A;T) / (G;G) / (G;T)
Type(s) : Effect Directly Studied
Groups : Not Available
Description : Associated with enhanced activation of the EGFR tyrosine kinase in patients with non-small cell lung cancer (NSCLC) recieving tyrosine kinase inhibitor therapy.
References :
- Lynch TJ, Bell DW, Sordella R, Gurubhagavatula S, Okimoto RA, Brannigan BW, Harris PL, Haserlat SM, Supko JG, Haluska FG, Louis DN, Christiani DC, Settleman J, Haber DA: Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med. 2004 May 20;350(21):2129-39. Epub 2004 Apr 29. [PubMed:15118073 ]
PMID: 17467171
Gefitinib
Product: Adapalene (sodium salt)
Identifier : DBSNPE004639
Drug : DB00317 (Gefitinib)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*3
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer.
References :
- Iressa® (gefitinib) tablets[package insert]. Wilmington, Delaware: AsdivaZeneca Pharmaceuticals LP; 2015. [Link]
PMID: 23773140
Gefitinib
Product: Adapalene
Identifier : DBSNPE004640
Drug : DB00317 (Gefitinib)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*4
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer.
References :
- Iressa® (gefitinib) tablets[package insert]. Wilmington, Delaware: AsdivaZeneca Pharmaceuticals LP; 2015. [Link]
PMID: 20605904
Gefitinib
Product: Acarbose (sulfate)
Identifier : DBSNPE004641
Drug : DB00317 (Gefitinib)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*5
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer.
References :
- Iressa® (gefitinib) tablets[package insert]. Wilmington, Delaware: AsdivaZeneca Pharmaceuticals LP; 2015. [Link]
PMID: 19371629
Gefitinib
Product: Acarbose
Identifier : DBSNPE004642
Drug : DB00317 (Gefitinib)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*6
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer.
References :
- Iressa® (gefitinib) tablets[package insert]. Wilmington, Delaware: AsdivaZeneca Pharmaceuticals LP; 2015. [Link]
PMID: 16118208
Gefitinib
Product: Prasugrel (Maleic acid)
Identifier : DBSNPE004643
Drug : DB00317 (Gefitinib)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*7
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer.
References :
- Iressa® (gefitinib) tablets[package insert]. Wilmington, Delaware: AsdivaZeneca Pharmaceuticals LP; 2015. [Link]
PMID: 24131448
Gefitinib
Product: Prasugrel (hydrochloride)
Identifier : DBSNPE004644
Drug : DB00317 (Gefitinib)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*8
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer.
References :
- Iressa® (gefitinib) tablets[package insert]. Wilmington, Delaware: AsdivaZeneca Pharmaceuticals LP; 2015. [Link]
PMID: 23562243
Gefitinib
Product: Posaconazole (hydrate)
Identifier : DBSNPE004645
Drug : DB00317 (Gefitinib)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*11
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer.
References :
- Iressa® (gefitinib) tablets[package insert]. Wilmington, Delaware: AsdivaZeneca Pharmaceuticals LP; 2015. [Link]
PMID: 23592516
Gefitinib
Product: Entecavir (monohydrate)
Identifier : DBSNPE004646
Drug : DB00317 (Gefitinib)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*12
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer.
References :
- Iressa® (gefitinib) tablets[package insert]. Wilmington, Delaware: AsdivaZeneca Pharmaceuticals LP; 2015. [Link]
PMID: 18418891
Gefitinib
Product: Dienogest
Identifier : DBSNPE004647
Drug : DB00317 (Gefitinib)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- CYP2D7/2D6 hybrid gene sdivucture
Allele Name : CYP2D6*13
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer.
References :
- Iressa® (gefitinib) tablets[package insert]. Wilmington, Delaware: AsdivaZeneca Pharmaceuticals LP; 2015. [Link]
PMID: 17668877
Gefitinib
Product: Leflunomide
Identifier : DBSNPE004648
Drug : DB00317 (Gefitinib)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*14A
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer.
References :
- Iressa® (gefitinib) tablets[package insert]. Wilmington, Delaware: AsdivaZeneca Pharmaceuticals LP; 2015. [Link]
PMID: 17854798
Gefitinib
Product: Agomelatine (L(+)-Tartaric acid)
Identifier : DBSNPE004649
Drug : DB00317 (Gefitinib)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*15
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer.
References :
- Iressa® (gefitinib) tablets[package insert]. Wilmington, Delaware: AsdivaZeneca Pharmaceuticals LP; 2015. [Link]
PMID: 26459563
Gefitinib
Product: Agomelatine (hydrochloride)
Identifier : DBSNPE004650
Drug : DB00317 (Gefitinib)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- 2539_2542delAACT (rs72549353 )
Allele Name : CYP2D6*19
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer.
References :
- Iressa® (gefitinib) tablets[package insert]. Wilmington, Delaware: AsdivaZeneca Pharmaceuticals LP; 2015. [Link]
PMID: 22582137
Gefitinib
Product: Vincristine (sulfate)
Identifier : DBSNPE004651
Drug : DB00317 (Gefitinib)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- 1973_1974insG (rs72549354 )
Allele Name : CYP2D6*20
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer.
References :
- Iressa® (gefitinib) tablets[package insert]. Wilmington, Delaware: AsdivaZeneca Pharmaceuticals LP; 2015. [Link]
PMID: 8528578
Gefitinib
Product: Folinic acid (calcium salt pentahydrate)
Identifier : DBSNPE004652
Drug : DB00317 (Gefitinib)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*21
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer.
References :
- Iressa® (gefitinib) tablets[package insert]. Wilmington, Delaware: AsdivaZeneca Pharmaceuticals LP; 2015. [Link]
PMID: 7813579
Gefitinib
Product: Letrozole
Identifier : DBSNPE004653
Drug : DB00317 (Gefitinib)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- -1770G>A
- -1584C>G
- -1235A>G
- -740C>T
- -678G>A
- CYP2D7 gene conversion in indivon 1
- 310G>T
- 746C>G
- 843T>G
- 1661G>C
- 2850C>T
- 3384A>C
- 3584G>A
- 3790C>T
- 4042G>A
- 4180G>C
- 4481G>A
Allele Name : CYP2D6*31
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer.
References :
- Iressa® (gefitinib) tablets[package insert]. Wilmington, Delaware: AsdivaZeneca Pharmaceuticals LP; 2015. [Link]
PMID: 8422387
Gefitinib
Product: Raloxifene (hydrochloride)
Identifier : DBSNPE004654
Drug : DB00317 (Gefitinib)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- 100C>T (rs1065852 )
- -1426C>T
- variable number of A’s in the region -1258 to -1237a
- -1235A>G
- -1000G>A
- 1039C>T
- 1661G>C
- gene conversion to CYP2D7 in exon 9
- 4180G>C
Allele Name : CYP2D6*36
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer.
References :
- Iressa® (gefitinib) tablets[package insert]. Wilmington, Delaware: AsdivaZeneca Pharmaceuticals LP; 2015. [Link]
PMID: 24710004
Gefitinib
Product: Etoposide
Identifier : DBSNPE004655
Drug : DB00317 (Gefitinib)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- 2587_2590delGACT (rs72549351 )
Allele Name : CYP2D6*38
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer.
References :
- Iressa® (gefitinib) tablets[package insert]. Wilmington, Delaware: AsdivaZeneca Pharmaceuticals LP; 2015. [Link]
PMID: 22802704
Gefitinib
Product: Epirubicin (hydrochloride)
Identifier : DBSNPE004656
Drug : DB00317 (Gefitinib)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- 1863_1864ins(TTT CGC CCC)2 (rs72549356 )
Allele Name : CYP2D6*40
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer.
References :
- Iressa® (gefitinib) tablets[package insert]. Wilmington, Delaware: AsdivaZeneca Pharmaceuticals LP; 2015. [Link]
PMID: 20889759
Gefitinib
Product: Dacarbazine
Identifier : DBSNPE004657
Drug : DB00317 (Gefitinib)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- 3259_3260insGT (rs72549346 )
Allele Name : CYP2D6*42
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer.
References :
- Iressa® (gefitinib) tablets[package insert]. Wilmington, Delaware: AsdivaZeneca Pharmaceuticals LP; 2015. [Link]
PMID: 20574537
Gefitinib
Product: Bendamustine (hydrochloride)
Identifier : DBSNPE004658
Drug : DB00317 (Gefitinib)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*44
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer.
References :
- Iressa® (gefitinib) tablets[package insert]. Wilmington, Delaware: AsdivaZeneca Pharmaceuticals LP; 2015. [Link]
PMID: 20351057
Gefitinib
Product: (±)-Bisoprolol (hemifumarate)
Identifier : DBSNPE004659
Drug : DB00317 (Gefitinib)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- 100C>T (rs1065852 )
- -1426C>T
- -1235A>G
- -1000G>A
- 73C<T
- 1039C>T
- 1661G>C
- 4180G>C
Allele Name : CYP2D6*47
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer.
References :
- Iressa® (gefitinib) tablets[package insert]. Wilmington, Delaware: AsdivaZeneca Pharmaceuticals LP; 2015. [Link]
PMID: 21461354
Gefitinib
Product: Melatonin
Identifier : DBSNPE004660
Drug : DB00317 (Gefitinib)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- -1584C>G
- -1235A>G
- -740C>T
- -678G>A
- CYP2D7 gene conversion in indivon 1
- 1661G>C
- 2850C>T
- 3172A>C
- 4180G>C
Allele Name : CYP2D6*51
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer.
References :
- Iressa® (gefitinib) tablets[package insert]. Wilmington, Delaware: AsdivaZeneca Pharmaceuticals LP; 2015. [Link]
PMID: 7851504
Gefitinib
Product: Finasteride (acetate)
Identifier : DBSNPE004661
Drug : DB00317 (Gefitinib)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*56
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer.
References :
- Iressa® (gefitinib) tablets[package insert]. Wilmington, Delaware: AsdivaZeneca Pharmaceuticals LP; 2015. [Link]
PMID: 7510950
Gefitinib
Product: Finasteride
Identifier : DBSNPE004662
Drug : DB00317 (Gefitinib)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- 100C>T
- 310G>T
- 843T>G
- 887C>T
- 1039C>T
- 1661G>C
- 3384A>C
- 3582A>G
- gene conversion to CYP2D7 in exon 9
- 4180G>C
Allele Name : CYP2D6*57
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer.
References :
- Iressa® (gefitinib) tablets[package insert]. Wilmington, Delaware: AsdivaZeneca Pharmaceuticals LP; 2015. [Link]
PMID: 7535234
Gefitinib
Product: Exemestane
Identifier : DBSNPE004663
Drug : DB00317 (Gefitinib)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*62
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer.
References :
- Iressa® (gefitinib) tablets[package insert]. Wilmington, Delaware: AsdivaZeneca Pharmaceuticals LP; 2015. [Link]
PMID: 8832069
Gefitinib
Product: Valproic acid
Identifier : DBSNPE004664
Drug : DB00317 (Gefitinib)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- -1426C>T
- -1235A>G
- -1000G>A
- 100C>T
- 310G>T
- CYP2D7 sequence from indivon 1 onwards
Allele Name : CYP2D6*68A
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer.
References :
- Iressa® (gefitinib) tablets[package insert]. Wilmington, Delaware: AsdivaZeneca Pharmaceuticals LP; 2015. [Link]
PMID: 23261866
Gefitinib
Product: Valproic acid (sodium salt)
Identifier : DBSNPE004665
Drug : DB00317 (Gefitinib)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- Similar but not identical switch region compared to CYP2D6*68A. Found in tandem arrangement with CYP2D6*4.
Allele Name : CYP2D6*68B
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer.
References :
- Iressa® (gefitinib) tablets[package insert]. Wilmington, Delaware: AsdivaZeneca Pharmaceuticals LP; 2015. [Link]
PMID: 23690783
Gefitinib
Product: Cisplatin
Identifier : DBSNPE004666
Drug : DB00317 (Gefitinib)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- 2988G>A (rs28371725 )
- -1426C>T
- -1235A>G
- -1000G>A
- 100C>T
- 310G>T
- 746C>G
- 843T>G
- 1062A>G
- 1661G>C
- 2850C>T
- 3384A>C
- 3584G>A
- 3790C>T
- 4180G>C
- 4401C>T
- 4481G>A
Allele Name : CYP2D6*69
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer.
References :
- Iressa® (gefitinib) tablets[package insert]. Wilmington, Delaware: AsdivaZeneca Pharmaceuticals LP; 2015. [Link]
PMID: 19657070
Gefitinib
Product: GDC-0032
Identifier : DBSNPE004667
Drug : DB00317 (Gefitinib)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*92
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer.
References :
- Iressa® (gefitinib) tablets[package insert]. Wilmington, Delaware: AsdivaZeneca Pharmaceuticals LP; 2015. [Link]
PMID: 8884206
Gefitinib
Product: LY2334737
Identifier : DBSNPE004668
Drug : DB00317 (Gefitinib)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- -1426C>T
- -1235A>G
- -1109C>T
- -1000G>A
- 100C>T
- 310G>T
- 843T>G
- 1039C>T
- 1661G>C
- 2097A>G
- 2828delC
- 3384A>C
- 3582A>G
- 4180G>C
- 4401C>T
Allele Name : CYP2D6*100
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer.
References :
- Iressa® (gefitinib) tablets[package insert]. Wilmington, Delaware: AsdivaZeneca Pharmaceuticals LP; 2015. [Link]
PMID: 7533610
Gefitinib
Product: RN486
Identifier : DBSNPE004669
Drug : DB00317 (Gefitinib)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- -1426C>T
- -1235A>G
- -1000G>A
- 100C>T
- 310G>T
- 843T>G
- 1039C>T
- 1661G>C
- 2097A>G
- 2927_2945delGATCCTACATCCGGATGTG
- 3384A>C
- 3582A>G
- 4180G>C
- 4401C>T
Allele Name : CYP2D6*101
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer.
References :
- Iressa® (gefitinib) tablets[package insert]. Wilmington, Delaware: AsdivaZeneca Pharmaceuticals LP; 2015. [Link]
PMID: 7693279