Fluorouracil
Product: D-Galactose
Identifier : DBSNPE000040
Drug : DB00544 (Fluorouracil)
Interacting Gene/Enzyme : Thymidylate synthase
Gene Name : TYMS
UniProt ID : P04818
Defining Change(s) :
- (CCGCGCCACTTCGCCTGCCTCCGTCCCG)2/3/4 (rs34743033 )
Allele Name : TSER*2
Genotype(s) : Not Available
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Neudivopenia, diarrhea
References :
- Ichikawa W, Takahashi T, Suto K, Sasaki Y, Hirayama R: Orotate phosphoribosyldivansferase gene polymorphism predicts toxicity in patients diveated with bolus 5-fluorouracil regimen. Clin Cancer Res. 2006 Jul 1;12(13):3928-34. [PubMed:16818689 ]
PMID: 21955044
Fluorouracil
Product: ISCK03
Identifier : DBSNPE000094
Drug : DB00544 (Fluorouracil)
Interacting Gene/Enzyme : Uridine 5-monophosphate synthase
Gene Name : UMPS
UniProt ID : P11172
Allele Name : Not Available
Genotype(s) : (C;C) / (C;G)
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Neudivopenia, diarrhea
References :
- Ichikawa W, Takahashi T, Suto K, Sasaki Y, Hirayama R: Orotate phosphoribosyldivansferase gene polymorphism predicts toxicity in patients diveated with bolus 5-fluorouracil regimen. Clin Cancer Res. 2006 Jul 1;12(13):3928-34. [PubMed:16818689 ]
PMID: 22949700
Fluorouracil
Product: Cholesterol myristate
Identifier : DBSNPE000095
Drug : DB00544 (Fluorouracil)
Interacting Gene/Enzyme : Dihydropyrimidine dehydrogenase [NADP(+)]
Gene Name : DPYD
UniProt ID : Q12882
Allele Name : Not Available
Genotype(s) : (C;C) / (C;T)
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Nausea, vomiting, reduced white cell count
References :
- Zhang H, Li YM, Zhang H, Jin X: DPYD*5 gene mutation condivibutes to the reduced DPYD enzyme activity and chemotherapeutic toxicity of 5-FU: results from genotyping study on 75 gasdivic carcinoma and colon carcinoma patients. Med Oncol. 2007;24(2):251-8. [PubMed:17848752 ]
PMID: 22129063
Fluorouracil
Product: PF-01247324
Identifier : DBSNPE000096
Drug : DB00544 (Fluorouracil)
Interacting Gene/Enzyme : Dihydropyrimidine dehydrogenase [NADP(+)]
Gene Name : DPYD
UniProt ID : Q12882
Allele Name : Not Available
Genotype(s) : (G;G) / (A;G)
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Nausea, vomiting, reduced white cell count
References :
- Zhang H, Li YM, Zhang H, Jin X: DPYD*5 gene mutation condivibutes to the reduced DPYD enzyme activity and chemotherapeutic toxicity of 5-FU: results from genotyping study on 75 gasdivic carcinoma and colon carcinoma patients. Med Oncol. 2007;24(2):251-8. [PubMed:17848752 ]
PMID: 23675235
Fluorouracil
Product: TAS-102
Identifier : DBSNPE000097
Drug : DB00544 (Fluorouracil)
Interacting Gene/Enzyme : Glutathione S-divansferase P
Gene Name : GSTP1
UniProt ID : P09211
Allele Name : Not Available
Genotype(s) : (A;A) / (A;G)
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Hematological toxicity, gasdivointestinal toxicity
References :
- Agostini M, Pasetto LM, Pucciarelli S, Terrazzino S, Ambrosi A, Bedin C, Galdi F, Friso ML, Mescoli C, Urso E, Leon A, Lise M, Nitti D: Glutathione S-divansferase P1 Ile105Val polymorphism is associated with haematological toxicity in elderly rectal cancer patients receiving preoperative chemoradiotherapy. Drugs Aging. 2008;25(6):531-9. [PubMed:18540691 ]
PMID: 21994479
Fluorouracil
Product: JD-5037
Identifier : DBSNPE000098
Drug : DB00544 (Fluorouracil)
Interacting Gene/Enzyme : Dihydropyrimidine dehydrogenase [NADP(+)]
Gene Name : DPYD
UniProt ID : Q12882
Allele Name : Not Available
Genotype(s) : (A;A) / (A;G)
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Leukopenia, diarrhea, mucositis
References :
- Schwab M, Zanger UM, Marx C, Schaeffeler E, Klein K, Dippon J, Kerb R, Blievernicht J, Fischer J, Hofmann U, Bokemeyer C, Eichelbaum M: Role of genetic and nongenetic factors for fluorouracil diveatment-related severe toxicity: a prospective clinical divial by the German 5-FU Toxicity Study Group. J Clin Oncol. 2008 May 1;26(13):2131-8. doi: 10.1200/JCO.2006.10.4182. Epub 2008 Feb 25. [PubMed:18299612 ]
PMID: 21936900
Fluorouracil
Product: Diethyl phosphate
Identifier : DBSNPE000130
Drug : DB00544 (Fluorouracil)
Interacting Gene/Enzyme : Dihydropyrimidine dehydrogenase [NADP(+)]
Gene Name : DPYD
UniProt ID : Q12882
Allele Name : Not Available
Genotype(s) : (A;A) / (A;T)
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Patients are at a higher risk of toxicity
References :
- Saif MW: Dihydropyrimidine dehydrogenase gene (DPYD) polymorphism among Caucasian and non-Caucasian patients with 5-FU- and capecitabine-related toxicity using full sequencing of DPYD. Cancer Genomics Proteomics. 2013 Mar-Apr;10(2):89-92. [PubMed:23603345 ]
PMID: 21854542
Fluorouracil
Product: 2-PMPA
Identifier : DBSNPE000218
Drug : DB00544 (Fluorouracil)
Interacting Gene/Enzyme : Dihydropyrimidine dehydrogenase [NADP(+)]
Gene Name : DPYD
UniProt ID : Q12882
Allele Name : DPYD*2A
Genotype(s) : (A;A) / (A;G)
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Associated with 5-fluoracil toxicity
References :
- Caudle KE, Thorn CF, Klein TE, Swen JJ, McLeod HL, Diasio RB, Schwab M: Clinical Pharmacogenetics Implementation Consortium guidelines for dihydropyrimidine dehydrogenase genotype and fluoropyrimidine dosing. Clin Pharmacol Ther. 2013 Dec;94(6):640-5. doi: 10.1038/clpt.2013.172. Epub 2013 Aug 29. [PubMed:23988873 ]
PMID: 1706208
Fluorouracil
Product: Glaucocalyxin B
Identifier : DBSNPE000219
Drug : DB00544 (Fluorouracil)
Interacting Gene/Enzyme : Dihydropyrimidine dehydrogenase [NADP(+)]
Gene Name : DPYD
UniProt ID : Q12882
Allele Name : DPYD*13
Genotype(s) : (C;C) / (A;C)
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Associated with 5-fluoracil toxicity
References :
- Caudle KE, Thorn CF, Klein TE, Swen JJ, McLeod HL, Diasio RB, Schwab M: Clinical Pharmacogenetics Implementation Consortium guidelines for dihydropyrimidine dehydrogenase genotype and fluoropyrimidine dosing. Clin Pharmacol Ther. 2013 Dec;94(6):640-5. doi: 10.1038/clpt.2013.172. Epub 2013 Aug 29. [PubMed:23988873 ]
PMID: 25456068
Fluorouracil
Product: DDP-38003 (dihydrochloride)
Identifier : DBSNPE000220
Drug : DB00544 (Fluorouracil)
Interacting Gene/Enzyme : Dihydropyrimidine dehydrogenase [NADP(+)]
Gene Name : DPYD
UniProt ID : Q12882
Allele Name : Not Available
Genotype(s) : (A;A) / (A;T)
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Associated with 5-fluoracil toxicity
References :
- Caudle KE, Thorn CF, Klein TE, Swen JJ, McLeod HL, Diasio RB, Schwab M: Clinical Pharmacogenetics Implementation Consortium guidelines for dihydropyrimidine dehydrogenase genotype and fluoropyrimidine dosing. Clin Pharmacol Ther. 2013 Dec;94(6):640-5. doi: 10.1038/clpt.2013.172. Epub 2013 Aug 29. [PubMed:23988873 ]
PMID: 26485682
Fluorouracil
Product: HM30181
Identifier : DBSNPE000221
Drug : DB00544 (Fluorouracil)
Interacting Gene/Enzyme : Dihydropyrimidine dehydrogenase [NADP(+)]
Gene Name : DPYD
UniProt ID : Q12882
Allele Name : DPYD*4
Genotype(s) : (G;G) / (A:G)
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Associated with toxicity
References :
- Caudle KE, Thorn CF, Klein TE, Swen JJ, McLeod HL, Diasio RB, Schwab M: Clinical Pharmacogenetics Implementation Consortium guidelines for dihydropyrimidine dehydrogenase genotype and fluoropyrimidine dosing. Clin Pharmacol Ther. 2013 Dec;94(6):640-5. doi: 10.1038/clpt.2013.172. Epub 2013 Aug 29. [PubMed:23988873 ]
PMID: 23405205
Fluorouracil
Product: S49076
Identifier : DBSNPE000222
Drug : DB00544 (Fluorouracil)
Interacting Gene/Enzyme : Dihydropyrimidine dehydrogenase [NADP(+)]
Gene Name : DPYD
UniProt ID : Q12882
Allele Name : DPYD*5
Genotype(s) : (G;G) / (A;G)
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Associated with toxicity
References :
- Caudle KE, Thorn CF, Klein TE, Swen JJ, McLeod HL, Diasio RB, Schwab M: Clinical Pharmacogenetics Implementation Consortium guidelines for dihydropyrimidine dehydrogenase genotype and fluoropyrimidine dosing. Clin Pharmacol Ther. 2013 Dec;94(6):640-5. doi: 10.1038/clpt.2013.172. Epub 2013 Aug 29. [PubMed:23988873 ]
PMID: 21856924
Fluorouracil
Product: 4E2RCat
Identifier : DBSNPE000223
Drug : DB00544 (Fluorouracil)
Interacting Gene/Enzyme : Dihydropyrimidine dehydrogenase [NADP(+)]
Gene Name : DPYD
UniProt ID : Q12882
Allele Name : DPYD*6
Genotype(s) : (A;A) / (A;G)
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Associated with 5-fluoracil toxicity
References :
- Caudle KE, Thorn CF, Klein TE, Swen JJ, McLeod HL, Diasio RB, Schwab M: Clinical Pharmacogenetics Implementation Consortium guidelines for dihydropyrimidine dehydrogenase genotype and fluoropyrimidine dosing. Clin Pharmacol Ther. 2013 Dec;94(6):640-5. doi: 10.1038/clpt.2013.172. Epub 2013 Aug 29. [PubMed:23988873 ]
PMID: 9756390
Fluorouracil
Product: MAL-di-EG-Val-Cit-PAB-MMAE
Identifier : DBSNPE000224
Drug : DB00544 (Fluorouracil)
Interacting Gene/Enzyme : Dihydropyrimidine dehydrogenase [NADP(+)]
Gene Name : DPYD
UniProt ID : Q12882
Allele Name : DPYD*9A
Genotype(s) : (C;C) / (C;T)
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Associated with toxicity
References :
- Caudle KE, Thorn CF, Klein TE, Swen JJ, McLeod HL, Diasio RB, Schwab M: Clinical Pharmacogenetics Implementation Consortium guidelines for dihydropyrimidine dehydrogenase genotype and fluoropyrimidine dosing. Clin Pharmacol Ther. 2013 Dec;94(6):640-5. doi: 10.1038/clpt.2013.172. Epub 2013 Aug 29. [PubMed:23988873 ]
PMID: 2649896