PI3KInhibitorpi3kinhibitor

Escitalopram

By

Escitalopram

Product: Indole-3-butyric acid

Identifier : DBSNPE000136
Drug : DB01175 (Escitalopram)
Interacting Gene/Enzyme : Sodium-dependent serotonin divansporter
Gene Name : SLC6A4
UniProt ID : P31645
Defining Change(s) :

  • A allele (rs25531 )

Allele Name : Not Available
Genotype(s) : (A;A)
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Increase risk of side effects (ie. headaches)
References :

  1. Maron E, Tammiste A, Kallassalu K, Eller T, Vasar V, Nutt DJ, Metspalu A: Serotonin divansporter promoter region polymorphisms do not influence diveatment response to escitalopram in patients with major depression. Eur Neuropsychopharmacol. 2009 Jun;19(6):451-6. doi: 10.1016/j.euroneuro.2009.01.010. Epub 2009 Mar 9. [PubMed:19272758 ]

PMID: 21738764

Escitalopram

By

Escitalopram

Product: Reparixin

Identifier : DBSNPE005062
Drug : DB01175 (Escitalopram)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Defining Change(s) :

  • 681G>A (rs4244285 )

Allele Name : CYP2C19*2A
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2C19
Description : Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.
References :

  1. Hicks JK, Bishop JR, Sangkuhl K, Muller DJ, Ji Y, Leckband SG, Leeder JS, Graham RL, Chiulli DL, LLerena A, Skaar TC, Scott SA, Stingl JC, Klein TE, Caudle KE, Gaedigk A: Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors. Clin Pharmacol Ther. 2015 Aug;98(2):127-34. doi: 10.1002/cpt.147. Epub 2015 Jun 29. [PubMed:25974703 ]

PMID: 8126695

Escitalopram

By

Escitalopram

Product: Baricitinib (phosphate)

Identifier : DBSNPE005063
Drug : DB01175 (Escitalopram)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Defining Change(s) :

  • 681G>A (rs4244285 )

Allele Name : CYP2C19*2B
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2C19
Description : Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.
References :

  1. Hicks JK, Bishop JR, Sangkuhl K, Muller DJ, Ji Y, Leckband SG, Leeder JS, Graham RL, Chiulli DL, LLerena A, Skaar TC, Scott SA, Stingl JC, Klein TE, Caudle KE, Gaedigk A: Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors. Clin Pharmacol Ther. 2015 Aug;98(2):127-34. doi: 10.1002/cpt.147. Epub 2015 Jun 29. [PubMed:25974703 ]

PMID: 20554860

Escitalopram

By

Escitalopram

Product: MK-5172 (sodium salt)

Identifier : DBSNPE005064
Drug : DB01175 (Escitalopram)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Defining Change(s) :

  • 636G>A (rs4986893 )

Allele Name : CYP2C19*3
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2C19
Description : Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.
References :

  1. Hicks JK, Bishop JR, Sangkuhl K, Muller DJ, Ji Y, Leckband SG, Leeder JS, Graham RL, Chiulli DL, LLerena A, Skaar TC, Scott SA, Stingl JC, Klein TE, Caudle KE, Gaedigk A: Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors. Clin Pharmacol Ther. 2015 Aug;98(2):127-34. doi: 10.1002/cpt.147. Epub 2015 Jun 29. [PubMed:25974703 ]

PMID: 10694212

Escitalopram

By

Escitalopram

Product: MK-5172 (hydrate)

Identifier : DBSNPE005065
Drug : DB01175 (Escitalopram)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Defining Change(s) :

  • 1A>G (rs28399504 )

Allele Name : CYP2C19*4
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2C19
Description : Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.
References :

  1. Hicks JK, Bishop JR, Sangkuhl K, Muller DJ, Ji Y, Leckband SG, Leeder JS, Graham RL, Chiulli DL, LLerena A, Skaar TC, Scott SA, Stingl JC, Klein TE, Caudle KE, Gaedigk A: Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors. Clin Pharmacol Ther. 2015 Aug;98(2):127-34. doi: 10.1002/cpt.147. Epub 2015 Jun 29. [PubMed:25974703 ]

PMID: 10478574

Escitalopram

By

Escitalopram

Product: MK-5172 (potassium salt)

Identifier : DBSNPE005066
Drug : DB01175 (Escitalopram)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Defining Change(s) :

  • 1297C>T (rs56337013 )

Allele Name : CYP2C19*5
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2C19
Description : Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.
References :

  1. Hicks JK, Bishop JR, Sangkuhl K, Muller DJ, Ji Y, Leckband SG, Leeder JS, Graham RL, Chiulli DL, LLerena A, Skaar TC, Scott SA, Stingl JC, Klein TE, Caudle KE, Gaedigk A: Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors. Clin Pharmacol Ther. 2015 Aug;98(2):127-34. doi: 10.1002/cpt.147. Epub 2015 Jun 29. [PubMed:25974703 ]

PMID: 7473590

Escitalopram

By

Escitalopram

Product: MK-5172

Identifier : DBSNPE005067
Drug : DB01175 (Escitalopram)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Defining Change(s) :

  • 395G>A (rs72552267 )

Allele Name : CYP2C19*6
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2C19
Description : Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.
References :

  1. Hicks JK, Bishop JR, Sangkuhl K, Muller DJ, Ji Y, Leckband SG, Leeder JS, Graham RL, Chiulli DL, LLerena A, Skaar TC, Scott SA, Stingl JC, Klein TE, Caudle KE, Gaedigk A: Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors. Clin Pharmacol Ther. 2015 Aug;98(2):127-34. doi: 10.1002/cpt.147. Epub 2015 Jun 29. [PubMed:25974703 ]

PMID: 27995495

Escitalopram

By

Escitalopram

Product: Atrasentan (hydrochloride)

Identifier : DBSNPE005068
Drug : DB01175 (Escitalopram)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Defining Change(s) :

  • 19294T>A (rs72558186 )

Allele Name : CYP2C19*7
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2C19
Description : Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.
References :

  1. Hicks JK, Bishop JR, Sangkuhl K, Muller DJ, Ji Y, Leckband SG, Leeder JS, Graham RL, Chiulli DL, LLerena A, Skaar TC, Scott SA, Stingl JC, Klein TE, Caudle KE, Gaedigk A: Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors. Clin Pharmacol Ther. 2015 Aug;98(2):127-34. doi: 10.1002/cpt.147. Epub 2015 Jun 29. [PubMed:25974703 ]

PMID: 23259041

Escitalopram

By

Escitalopram

Product: Atrasentan

Identifier : DBSNPE005069
Drug : DB01175 (Escitalopram)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Defining Change(s) :

  • 557G>C (rs140278421 )
  • 991A>G

Allele Name : CYP2C19*22
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2C19
Description : Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.
References :

  1. Hicks JK, Bishop JR, Sangkuhl K, Muller DJ, Ji Y, Leckband SG, Leeder JS, Graham RL, Chiulli DL, LLerena A, Skaar TC, Scott SA, Stingl JC, Klein TE, Caudle KE, Gaedigk A: Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors. Clin Pharmacol Ther. 2015 Aug;98(2):127-34. doi: 10.1002/cpt.147. Epub 2015 Jun 29. [PubMed:25974703 ]

PMID: 17127363

Escitalopram

By

Escitalopram

Product: Amiodarone (hydrochloride)

Identifier : DBSNPE005070
Drug : DB01175 (Escitalopram)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Defining Change(s) :

  • 99C>T (rs17885098 )
  • 991A>G (rs3758581 )
  • 1004G>A (rs118203757 )
  • 1197A>G

Allele Name : CYP2C19*24
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2C19
Description : Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.
References :

  1. Hicks JK, Bishop JR, Sangkuhl K, Muller DJ, Ji Y, Leckband SG, Leeder JS, Graham RL, Chiulli DL, LLerena A, Skaar TC, Scott SA, Stingl JC, Klein TE, Caudle KE, Gaedigk A: Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors. Clin Pharmacol Ther. 2015 Aug;98(2):127-34. doi: 10.1002/cpt.147. Epub 2015 Jun 29. [PubMed:25974703 ]

PMID: 14699012

Escitalopram

By

Escitalopram

Product: Palifosfamide

Identifier : DBSNPE005071
Drug : DB01175 (Escitalopram)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Defining Change(s) :

  • 12662A>G (rs12769205 )

Allele Name : CYP2C19*35
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2C19
Description : Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.
References :

  1. Hicks JK, Bishop JR, Sangkuhl K, Muller DJ, Ji Y, Leckband SG, Leeder JS, Graham RL, Chiulli DL, LLerena A, Skaar TC, Scott SA, Stingl JC, Klein TE, Caudle KE, Gaedigk A: Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors. Clin Pharmacol Ther. 2015 Aug;98(2):127-34. doi: 10.1002/cpt.147. Epub 2015 Jun 29. [PubMed:25974703 ]

PMID: 15258850

Escitalopram

By

Escitalopram

Product: Reparixin

Identifier : DBSNPE005062
Drug : DB01175 (Escitalopram)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Defining Change(s) :

  • 681G>A (rs4244285 )

Allele Name : CYP2C19*2A
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2C19
Description : Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.
References :

  1. Hicks JK, Bishop JR, Sangkuhl K, Muller DJ, Ji Y, Leckband SG, Leeder JS, Graham RL, Chiulli DL, LLerena A, Skaar TC, Scott SA, Stingl JC, Klein TE, Caudle KE, Gaedigk A: Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors. Clin Pharmacol Ther. 2015 Aug;98(2):127-34. doi: 10.1002/cpt.147. Epub 2015 Jun 29. [PubMed:25974703 ]

PMID: 8126695

Escitalopram

By

Escitalopram

Product: Baricitinib (phosphate)

Identifier : DBSNPE005063
Drug : DB01175 (Escitalopram)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Defining Change(s) :

  • 681G>A (rs4244285 )

Allele Name : CYP2C19*2B
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2C19
Description : Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.
References :

  1. Hicks JK, Bishop JR, Sangkuhl K, Muller DJ, Ji Y, Leckband SG, Leeder JS, Graham RL, Chiulli DL, LLerena A, Skaar TC, Scott SA, Stingl JC, Klein TE, Caudle KE, Gaedigk A: Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors. Clin Pharmacol Ther. 2015 Aug;98(2):127-34. doi: 10.1002/cpt.147. Epub 2015 Jun 29. [PubMed:25974703 ]

PMID: 20554860

Escitalopram

By

Escitalopram

Product: MK-5172 (sodium salt)

Identifier : DBSNPE005064
Drug : DB01175 (Escitalopram)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Defining Change(s) :

  • 636G>A (rs4986893 )

Allele Name : CYP2C19*3
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2C19
Description : Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.
References :

  1. Hicks JK, Bishop JR, Sangkuhl K, Muller DJ, Ji Y, Leckband SG, Leeder JS, Graham RL, Chiulli DL, LLerena A, Skaar TC, Scott SA, Stingl JC, Klein TE, Caudle KE, Gaedigk A: Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors. Clin Pharmacol Ther. 2015 Aug;98(2):127-34. doi: 10.1002/cpt.147. Epub 2015 Jun 29. [PubMed:25974703 ]

PMID: 10694212

Escitalopram

By

Escitalopram

Product: MK-5172 (hydrate)

Identifier : DBSNPE005065
Drug : DB01175 (Escitalopram)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Defining Change(s) :

  • 1A>G (rs28399504 )

Allele Name : CYP2C19*4
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2C19
Description : Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.
References :

  1. Hicks JK, Bishop JR, Sangkuhl K, Muller DJ, Ji Y, Leckband SG, Leeder JS, Graham RL, Chiulli DL, LLerena A, Skaar TC, Scott SA, Stingl JC, Klein TE, Caudle KE, Gaedigk A: Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors. Clin Pharmacol Ther. 2015 Aug;98(2):127-34. doi: 10.1002/cpt.147. Epub 2015 Jun 29. [PubMed:25974703 ]

PMID: 10478574

Escitalopram

By

Escitalopram

Product: MK-5172 (potassium salt)

Identifier : DBSNPE005066
Drug : DB01175 (Escitalopram)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Defining Change(s) :

  • 1297C>T (rs56337013 )

Allele Name : CYP2C19*5
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2C19
Description : Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.
References :

  1. Hicks JK, Bishop JR, Sangkuhl K, Muller DJ, Ji Y, Leckband SG, Leeder JS, Graham RL, Chiulli DL, LLerena A, Skaar TC, Scott SA, Stingl JC, Klein TE, Caudle KE, Gaedigk A: Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors. Clin Pharmacol Ther. 2015 Aug;98(2):127-34. doi: 10.1002/cpt.147. Epub 2015 Jun 29. [PubMed:25974703 ]

PMID: 7473590

Escitalopram

By

Escitalopram

Product: MK-5172

Identifier : DBSNPE005067
Drug : DB01175 (Escitalopram)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Defining Change(s) :

  • 395G>A (rs72552267 )

Allele Name : CYP2C19*6
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2C19
Description : Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.
References :

  1. Hicks JK, Bishop JR, Sangkuhl K, Muller DJ, Ji Y, Leckband SG, Leeder JS, Graham RL, Chiulli DL, LLerena A, Skaar TC, Scott SA, Stingl JC, Klein TE, Caudle KE, Gaedigk A: Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors. Clin Pharmacol Ther. 2015 Aug;98(2):127-34. doi: 10.1002/cpt.147. Epub 2015 Jun 29. [PubMed:25974703 ]

PMID: 27995495

Escitalopram

By

Escitalopram

Product: Atrasentan (hydrochloride)

Identifier : DBSNPE005068
Drug : DB01175 (Escitalopram)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Defining Change(s) :

  • 19294T>A (rs72558186 )

Allele Name : CYP2C19*7
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2C19
Description : Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.
References :

  1. Hicks JK, Bishop JR, Sangkuhl K, Muller DJ, Ji Y, Leckband SG, Leeder JS, Graham RL, Chiulli DL, LLerena A, Skaar TC, Scott SA, Stingl JC, Klein TE, Caudle KE, Gaedigk A: Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors. Clin Pharmacol Ther. 2015 Aug;98(2):127-34. doi: 10.1002/cpt.147. Epub 2015 Jun 29. [PubMed:25974703 ]

PMID: 23259041

Escitalopram

By

Escitalopram

Product: Atrasentan

Identifier : DBSNPE005069
Drug : DB01175 (Escitalopram)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Defining Change(s) :

  • 557G>C (rs140278421 )
  • 991A>G

Allele Name : CYP2C19*22
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2C19
Description : Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.
References :

  1. Hicks JK, Bishop JR, Sangkuhl K, Muller DJ, Ji Y, Leckband SG, Leeder JS, Graham RL, Chiulli DL, LLerena A, Skaar TC, Scott SA, Stingl JC, Klein TE, Caudle KE, Gaedigk A: Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors. Clin Pharmacol Ther. 2015 Aug;98(2):127-34. doi: 10.1002/cpt.147. Epub 2015 Jun 29. [PubMed:25974703 ]

PMID: 17127363

Escitalopram

By

Escitalopram

Product: Amiodarone (hydrochloride)

Identifier : DBSNPE005070
Drug : DB01175 (Escitalopram)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Defining Change(s) :

  • 99C>T (rs17885098 )
  • 991A>G (rs3758581 )
  • 1004G>A (rs118203757 )
  • 1197A>G

Allele Name : CYP2C19*24
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2C19
Description : Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.
References :

  1. Hicks JK, Bishop JR, Sangkuhl K, Muller DJ, Ji Y, Leckband SG, Leeder JS, Graham RL, Chiulli DL, LLerena A, Skaar TC, Scott SA, Stingl JC, Klein TE, Caudle KE, Gaedigk A: Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors. Clin Pharmacol Ther. 2015 Aug;98(2):127-34. doi: 10.1002/cpt.147. Epub 2015 Jun 29. [PubMed:25974703 ]

PMID: 14699012

Escitalopram

By

Escitalopram

Product: Palifosfamide

Identifier : DBSNPE005071
Drug : DB01175 (Escitalopram)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Defining Change(s) :

  • 12662A>G (rs12769205 )

Allele Name : CYP2C19*35
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2C19
Description : Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.
References :

  1. Hicks JK, Bishop JR, Sangkuhl K, Muller DJ, Ji Y, Leckband SG, Leeder JS, Graham RL, Chiulli DL, LLerena A, Skaar TC, Scott SA, Stingl JC, Klein TE, Caudle KE, Gaedigk A: Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors. Clin Pharmacol Ther. 2015 Aug;98(2):127-34. doi: 10.1002/cpt.147. Epub 2015 Jun 29. [PubMed:25974703 ]

PMID: 15258850

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