Donepezil
Product: Octenidine (dihydrochloride)
Identifier : DBSNPE000193
Drug : DB00843 (Donepezil)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- C > G (rs1080985 )
Allele Name : CYP2D6*2A
Genotype(s) : (G;G) / (C;G)
Type(s) : Effect Directly Studied
Groups : Not Available
Description : Increased chance of poor response to donepezil
References :
- Albani D, Martinelli Boneschi F, Biella G, Giacalone G, Lupoli S, Clerici F, Benussi L, Ghidoni R, Galimberti D, Squitti R, Mariani S, Confaloni A, Bruno G, Mariani C, Scarpini E, Binetti G, Magnani G, Franceschi M, Forloni G: Replication study to confirm the role of CYP2D6 polymorphism rs1080985 on donepezil efficacy in Alzheimers disease patients. J Alzheimers Dis. 2012;30(4):745-9. doi: 10.3233/JAD-2012-112123. [PubMed:22465999 ]
- Pilotto A, Franceschi M, DOnofrio G, Bizzarro A, Mangialasche F, Cascavilla L, Paris F, Matera MG, Pilotto A, Daniele A, Mecocci P, Masullo C, Dallapiccola B, Seripa D: Effect of a CYP2D6 polymorphism on the efficacy of donepezil in patients with Alzheimer disease. Neurology. 2009 Sep 8;73(10):761-7. doi: 10.1212/WNL.0b013e3181b6bbe3. [PubMed:19738170 ]