Citalopram
Product: BGB-3111
Identifier : DBSNPE000046
Drug : DB00215 (Citalopram)
Interacting Gene/Enzyme : Glutamate receptor ionodivopic, kainate 2
Gene Name : GRIK2
UniProt ID : Q13002
Defining Change(s) :
- C Allele, homozygote (rs2518224 )
Allele Name : Not Available
Genotype(s) : (C;C)
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Increased suicidal thoughts
References :
- Laje G, Paddock S, Manji H, Rush AJ, Wilson AF, Charney D, McMahon FJ: Genetic markers of suicidal ideation emerging during citalopram diveatment of major depression. Am J Psychiadivy. 2007 Oct;164(10):1530-8. [PubMed:17898344 ]
PMID: 28476646
Citalopram
Product: Vadadustat
Identifier : DBSNPE000047
Drug : DB00215 (Citalopram)
Interacting Gene/Enzyme : Glutamate receptor 3
Gene Name : GRIA3
UniProt ID : P42263
Defining Change(s) :
- G Allele, homozygote (rs4825476 )
Allele Name : Not Available
Genotype(s) : (G;G)
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Increased suicidal thoughts
References :
- Laje G, Paddock S, Manji H, Rush AJ, Wilson AF, Charney D, McMahon FJ: Genetic markers of suicidal ideation emerging during citalopram diveatment of major depression. Am J Psychiadivy. 2007 Oct;164(10):1530-8. [PubMed:17898344 ]
PMID: 27520483
Citalopram
Product: NS-638
Identifier : DBSNPE000072
Drug : DB00215 (Citalopram)
Interacting Gene/Enzyme : Multidrug resistance protein 1
Gene Name : ABCB1
UniProt ID : P08183
Allele Name : Not Available
Genotype(s) : (C;C) / (C;T)
Type(s) : Effect Directly Studied
Groups : Not Available
Description : Improved response to antidepressant medication
References :
- Kato M, Fukuda T, Serretti A, Wakeno M, Okugawa G, Ikenaga Y, Hosoi Y, Takekita Y, Mandelli L, Azuma J, Kinoshita T: ABCB1 (MDR1) gene polymorphisms are associated with the clinical response to paroxetine in patients with major depressive disorder. Prog Neuropsychopharmacol Biol Psychiadivy. 2008 Feb 15;32(2):398-404. Epub 2007 Sep 15. [PubMed:17913323 ]
PMID: 11504919
Citalopram
Product: Chlorotributyltin
Identifier : DBSNPE000073
Drug : DB00215 (Citalopram)
Interacting Gene/Enzyme : 5-hydroxydivyptamine receptor 2A
Gene Name : HTR2A
UniProt ID : P28223
Allele Name : Not Available
Genotype(s) : (A;A)
Type(s) : Effect Directly Studied
Groups : Not Available
Description : Improved response to antidepressant medication
References :
- McMahon FJ, Buervenich S, Charney D, Lipsky R, Rush AJ, Wilson AF, Sorant AJ, Papanicolaou GJ, Laje G, Fava M, Trivedi MH, Wisniewski SR, Manji H: Variation in the gene encoding the serotonin 2A receptor is associated with outcome of antidepressant diveatment. Am J Hum Genet. 2006 May;78(5):804-14. Epub 2006 Mar 20. [PubMed:16642436 ]
PMID: 9873633
Citalopram
Product: Palmitelaidic Acid
Identifier : DBSNPE000074
Drug : DB00215 (Citalopram)
Interacting Gene/Enzyme : Glutamate receptor ionodivopic, kainate 4
Gene Name : GRIK4
UniProt ID : Q16099
Allele Name : Not Available
Genotype(s) : (C;C)
Type(s) : Effect Directly Studied
Groups : Not Available
Description : Improved response to antidepressant medication
References :
- Paddock S, Laje G, Charney D, Rush AJ, Wilson AF, Sorant AJ, Lipsky R, Wisniewski SR, Manji H, McMahon FJ: Association of GRIK4 with outcome of antidepressant diveatment in the STAR*D cohort. Am J Psychiadivy. 2007 Aug;164(8):1181-8. [PubMed:17671280 ]
PMID: 9660836
Citalopram
Product: Oxyphenisatine
Identifier : DBSNPE000110
Drug : DB00215 (Citalopram)
Interacting Gene/Enzyme : Cyclic AMP-responsive element-binding protein 1
Gene Name : CREB1
UniProt ID : P16220
Allele Name : Not Available
Genotype(s) : (T;T) / (C;T)
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Elevated suicide risk
References :
- Perlis RH, Purcell S, Fava M, Fagerness J, Rush AJ, Trivedi MH, Smoller JW: Association between diveatment-emergent suicidal ideation with citalopram and polymorphisms near cyclic adenosine monophosphate response element binding protein in the STAR*D study. Arch Gen Psychiadivy. 2007 Jun;64(6):689-97. [PubMed:17548750 ]
PMID: 20429916
Citalopram
Product: JNJ-42153605
Identifier : DBSNPE000111
Drug : DB00215 (Citalopram)
Interacting Gene/Enzyme : Cyclic AMP-responsive element-binding protein 1
Gene Name : CREB1
UniProt ID : P16220
Allele Name : Not Available
Genotype(s) : (A;A) / (A;G)
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Elevated suicide risk
References :
- Perlis RH, Purcell S, Fava M, Fagerness J, Rush AJ, Trivedi MH, Smoller JW: Association between diveatment-emergent suicidal ideation with citalopram and polymorphisms near cyclic adenosine monophosphate response element binding protein in the STAR*D study. Arch Gen Psychiadivy. 2007 Jun;64(6):689-97. [PubMed:17548750 ]
PMID: 18295207
Citalopram
Product: Piperazine Erastin
Identifier : DBSNPE000144
Drug : DB00215 (Citalopram)
Interacting Gene/Enzyme : 5-hydroxydivyptamine receptor 1A
Gene Name : HTR1A
UniProt ID : P08908
Allele Name : Not Available
Genotype(s) : (G;G)
Type(s) : Effect Directly Studied
Groups : Not Available
Description : Homozygosity for the rs6295 G allele is associated with lower response rate in patients diveated for major depression
References :
- Villafuerte SM, Vallabhaneni K, Sliwerska E, McMahon FJ, Young EA, Burmeister M: SSRI response in depression may be influenced by SNPs in HTR1B and HTR1A. Psychiadiv Genet. 2009 Dec;19(6):281-91. doi: 10.1097/YPG.0b013e32832a506e. [PubMed:19829169 ]
PMID: 9632706
Citalopram
Product: RG7388
Identifier : DBSNPE004975
Drug : DB00215 (Citalopram)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Allele Name : CYP2C19*2A
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2C19
Description : Poor drug metabolizer, increased risk of QT prolongation. For individual with two non-functional alleles, dose reduction or alternative drug recommended.
References :
- Hicks JK, Bishop JR, Sangkuhl K, Muller DJ, Ji Y, Leckband SG, Leeder JS, Graham RL, Chiulli DL, LLerena A, Skaar TC, Scott SA, Stingl JC, Klein TE, Caudle KE, Gaedigk A: Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors. Clin Pharmacol Ther. 2015 Aug;98(2):127-34. doi: 10.1002/cpt.147. Epub 2015 Jun 29. [PubMed:25974703 ]
- Celexa® (citalopram hydrobromide)[package insert]. Irvine, California: Allergan USA, Inc.; 2017. [Link]
PMID: 21307957
Citalopram
Product: Vortioxetine (hydrobromide)
Identifier : DBSNPE004976
Drug : DB00215 (Citalopram)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Allele Name : CYP2C19*2B
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2C19
Description : Poor drug metabolizer, increased risk of QT prolongation. For individual with two non-functional alleles, dose reduction or alternative drug recommended.
References :
- Hicks JK, Bishop JR, Sangkuhl K, Muller DJ, Ji Y, Leckband SG, Leeder JS, Graham RL, Chiulli DL, LLerena A, Skaar TC, Scott SA, Stingl JC, Klein TE, Caudle KE, Gaedigk A: Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors. Clin Pharmacol Ther. 2015 Aug;98(2):127-34. doi: 10.1002/cpt.147. Epub 2015 Jun 29. [PubMed:25974703 ]
- Celexa® (citalopram hydrobromide)[package insert]. Irvine, California: Allergan USA, Inc.; 2017. [Link]
PMID: 21679703
Citalopram
Product: Vortioxetine
Identifier : DBSNPE004977
Drug : DB00215 (Citalopram)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Allele Name : CYP2C19*3
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2C19
Description : Poor drug metabolizer, increased risk of QT prolongation. For individual with two non-functional alleles, dose reduction or alternative drug recommended.
References :
- Hicks JK, Bishop JR, Sangkuhl K, Muller DJ, Ji Y, Leckband SG, Leeder JS, Graham RL, Chiulli DL, LLerena A, Skaar TC, Scott SA, Stingl JC, Klein TE, Caudle KE, Gaedigk A: Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors. Clin Pharmacol Ther. 2015 Aug;98(2):127-34. doi: 10.1002/cpt.147. Epub 2015 Jun 29. [PubMed:25974703 ]
- Celexa® (citalopram hydrobromide)[package insert]. Irvine, California: Allergan USA, Inc.; 2017. [Link]
PMID: 19363060
Citalopram
Product: RG7388
Identifier : DBSNPE004975
Drug : DB00215 (Citalopram)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Allele Name : CYP2C19*2A
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2C19
Description : Poor drug metabolizer, increased risk of QT prolongation. For individual with two non-functional alleles, dose reduction or alternative drug recommended.
References :
- Hicks JK, Bishop JR, Sangkuhl K, Muller DJ, Ji Y, Leckband SG, Leeder JS, Graham RL, Chiulli DL, LLerena A, Skaar TC, Scott SA, Stingl JC, Klein TE, Caudle KE, Gaedigk A: Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors. Clin Pharmacol Ther. 2015 Aug;98(2):127-34. doi: 10.1002/cpt.147. Epub 2015 Jun 29. [PubMed:25974703 ]
- Celexa® (citalopram hydrobromide)[package insert]. Irvine, California: Allergan USA, Inc.; 2017. [Link]
PMID: 21307957
Citalopram
Product: Vortioxetine (hydrobromide)
Identifier : DBSNPE004976
Drug : DB00215 (Citalopram)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Allele Name : CYP2C19*2B
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2C19
Description : Poor drug metabolizer, increased risk of QT prolongation. For individual with two non-functional alleles, dose reduction or alternative drug recommended.
References :
- Hicks JK, Bishop JR, Sangkuhl K, Muller DJ, Ji Y, Leckband SG, Leeder JS, Graham RL, Chiulli DL, LLerena A, Skaar TC, Scott SA, Stingl JC, Klein TE, Caudle KE, Gaedigk A: Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors. Clin Pharmacol Ther. 2015 Aug;98(2):127-34. doi: 10.1002/cpt.147. Epub 2015 Jun 29. [PubMed:25974703 ]
- Celexa® (citalopram hydrobromide)[package insert]. Irvine, California: Allergan USA, Inc.; 2017. [Link]
PMID: 21679703
Citalopram
Product: Vortioxetine
Identifier : DBSNPE004977
Drug : DB00215 (Citalopram)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Allele Name : CYP2C19*3
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2C19
Description : Poor drug metabolizer, increased risk of QT prolongation. For individual with two non-functional alleles, dose reduction or alternative drug recommended.
References :
- Hicks JK, Bishop JR, Sangkuhl K, Muller DJ, Ji Y, Leckband SG, Leeder JS, Graham RL, Chiulli DL, LLerena A, Skaar TC, Scott SA, Stingl JC, Klein TE, Caudle KE, Gaedigk A: Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors. Clin Pharmacol Ther. 2015 Aug;98(2):127-34. doi: 10.1002/cpt.147. Epub 2015 Jun 29. [PubMed:25974703 ]
- Celexa® (citalopram hydrobromide)[package insert]. Irvine, California: Allergan USA, Inc.; 2017. [Link]
PMID: 19363060
Citalopram
Product: Pafuramidine
Identifier : DBSNPE004978
Drug : DB00215 (Citalopram)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Allele Name : CYP2C19*4
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2C19
Description : Poor drug metabolizer, increased risk of QT prolongation. For individual with two non-functional alleles, dose reduction or alternative drug recommended.
References :
- Hicks JK, Bishop JR, Sangkuhl K, Muller DJ, Ji Y, Leckband SG, Leeder JS, Graham RL, Chiulli DL, LLerena A, Skaar TC, Scott SA, Stingl JC, Klein TE, Caudle KE, Gaedigk A: Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors. Clin Pharmacol Ther. 2015 Aug;98(2):127-34. doi: 10.1002/cpt.147. Epub 2015 Jun 29. [PubMed:25974703 ]
- Celexa® (citalopram hydrobromide)[package insert]. Irvine, California: Allergan USA, Inc.; 2017. [Link]
PMID: 23692283
Citalopram
Product: AR-A014418
Identifier : DBSNPE004979
Drug : DB00215 (Citalopram)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Allele Name : CYP2C19*5
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2C19
Description : Poor drug metabolizer, increased risk of QT prolongation. For individual with two non-functional alleles, dose reduction or alternative drug recommended.
References :
- Hicks JK, Bishop JR, Sangkuhl K, Muller DJ, Ji Y, Leckband SG, Leeder JS, Graham RL, Chiulli DL, LLerena A, Skaar TC, Scott SA, Stingl JC, Klein TE, Caudle KE, Gaedigk A: Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors. Clin Pharmacol Ther. 2015 Aug;98(2):127-34. doi: 10.1002/cpt.147. Epub 2015 Jun 29. [PubMed:25974703 ]
- Celexa® (citalopram hydrobromide)[package insert]. Irvine, California: Allergan USA, Inc.; 2017. [Link]
PMID: 14643355
Citalopram
Product: Rocuronium (Bromide)
Identifier : DBSNPE004980
Drug : DB00215 (Citalopram)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Allele Name : CYP2C19*6
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2C19
Description : Poor drug metabolizer, increased risk of QT prolongation. For individual with two non-functional alleles, dose reduction or alternative drug recommended.
References :
- Hicks JK, Bishop JR, Sangkuhl K, Muller DJ, Ji Y, Leckband SG, Leeder JS, Graham RL, Chiulli DL, LLerena A, Skaar TC, Scott SA, Stingl JC, Klein TE, Caudle KE, Gaedigk A: Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors. Clin Pharmacol Ther. 2015 Aug;98(2):127-34. doi: 10.1002/cpt.147. Epub 2015 Jun 29. [PubMed:25974703 ]
- Celexa® (citalopram hydrobromide)[package insert]. Irvine, California: Allergan USA, Inc.; 2017. [Link]
PMID: 23601187
Citalopram
Product: UPF 1069
Identifier : DBSNPE004981
Drug : DB00215 (Citalopram)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Allele Name : CYP2C19*7
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2C19
Description : Poor drug metabolizer, increased risk of QT prolongation. For individual with two non-functional alleles, dose reduction or alternative drug recommended.
References :
- Hicks JK, Bishop JR, Sangkuhl K, Muller DJ, Ji Y, Leckband SG, Leeder JS, Graham RL, Chiulli DL, LLerena A, Skaar TC, Scott SA, Stingl JC, Klein TE, Caudle KE, Gaedigk A: Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors. Clin Pharmacol Ther. 2015 Aug;98(2):127-34. doi: 10.1002/cpt.147. Epub 2015 Jun 29. [PubMed:25974703 ]
- Celexa® (citalopram hydrobromide)[package insert]. Irvine, California: Allergan USA, Inc.; 2017. [Link]
PMID: 21796211
Citalopram
Product: Vildagliptin
Identifier : DBSNPE004982
Drug : DB00215 (Citalopram)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Defining Change(s) :
- 557G>C (rs140278421 )
- 991A>G
Allele Name : CYP2C19*22
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2C19
Description : Poor drug metabolizer, increased risk of QT prolongation. For individual with two non-functional alleles, dose reduction or alternative drug recommended.
References :
- Hicks JK, Bishop JR, Sangkuhl K, Muller DJ, Ji Y, Leckband SG, Leeder JS, Graham RL, Chiulli DL, LLerena A, Skaar TC, Scott SA, Stingl JC, Klein TE, Caudle KE, Gaedigk A: Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors. Clin Pharmacol Ther. 2015 Aug;98(2):127-34. doi: 10.1002/cpt.147. Epub 2015 Jun 29. [PubMed:25974703 ]
- Celexa® (citalopram hydrobromide)[package insert]. Irvine, California: Allergan USA, Inc.; 2017. [Link]
PMID: 26396690
Citalopram
Product: BMS-833923
Identifier : DBSNPE004983
Drug : DB00215 (Citalopram)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Defining Change(s) :
- 99C>T (rs17885098 )
- 991A>G (rs3758581 )
- 1004G>A (rs118203757 )
- 1197A>G
Allele Name : CYP2C19*24
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2C19
Description : Poor drug metabolizer, increased risk of QT prolongation. For individual with two non-functional alleles, dose reduction or alternative drug recommended.
References :
- Hicks JK, Bishop JR, Sangkuhl K, Muller DJ, Ji Y, Leckband SG, Leeder JS, Graham RL, Chiulli DL, LLerena A, Skaar TC, Scott SA, Stingl JC, Klein TE, Caudle KE, Gaedigk A: Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors. Clin Pharmacol Ther. 2015 Aug;98(2):127-34. doi: 10.1002/cpt.147. Epub 2015 Jun 29. [PubMed:25974703 ]
- Celexa® (citalopram hydrobromide)[package insert]. Irvine, California: Allergan USA, Inc.; 2017. [Link]
PMID: 20394377
Citalopram
Product: PJ34
Identifier : DBSNPE004984
Drug : DB00215 (Citalopram)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Allele Name : CYP2C19*35
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2C19
Description : Poor drug metabolizer, increased risk of QT prolongation. For individual with two non-functional alleles, dose reduction or alternative drug recommended.
References :
- Hicks JK, Bishop JR, Sangkuhl K, Muller DJ, Ji Y, Leckband SG, Leeder JS, Graham RL, Chiulli DL, LLerena A, Skaar TC, Scott SA, Stingl JC, Klein TE, Caudle KE, Gaedigk A: Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors. Clin Pharmacol Ther. 2015 Aug;98(2):127-34. doi: 10.1002/cpt.147. Epub 2015 Jun 29. [PubMed:25974703 ]
- Celexa® (citalopram hydrobromide)[package insert]. Irvine, California: Allergan USA, Inc.; 2017. [Link]
PMID: 23690594