Cetuximab

By July 6, 2017

Identifier : DBSNPE000153

Drug : DB00002 (Cetuximab)

Interacting Gene/Enzyme : Low affinity immunoglobulin gamma Fc region receptor II-a

Gene Name : FCGR2A

UniProt ID : P12318

Defining Change(s) :

Allele Name : Not Available

Genotype(s) : (T;T) / (C;T)

Type(s) : Effect Directly Studied

Groups : Not Available

Description : Increased progression free survival

References :

Zhang W, Gordon M, Schultheis AM, Yang DY, Nagashima F, Azuma M, Chang HM, Borucka E, Lurje G, Sherrod AE, Iqbal S, Groshen S, Lenz HJ: FCGR2A and FCGR3A polymorphisms associated with clinical outcome of epidermal growth factor receptor expressing metastatic colorectal cancer patients diveated with single-agent cetuximab. J Clin Oncol. 2007 Aug 20;25(24):3712-8. [PubMed:17704420 ]

By July 6, 2017

Identifier : DBSNPE000161

Drug : DB00002 (Cetuximab)

Interacting Gene/Enzyme : Low affinity immunoglobulin gamma Fc region receptor III-A

Gene Name : FCGR3A

UniProt ID : P08637

Defining Change(s) :

Allele Name : Not Available

Genotype(s) : (T;T) / (G;T)

Type(s) : Effect Directly Studied

Groups : Not Available

Description : Better response to drug therapy (longer progression free survival) with the F allele

References :

Zhang W, Gordon M, Schultheis AM, Yang DY, Nagashima F, Azuma M, Chang HM, Borucka E, Lurje G, Sherrod AE, Iqbal S, Groshen S, Lenz HJ: FCGR2A and FCGR3A polymorphisms associated with clinical outcome of epidermal growth factor receptor expressing metastatic colorectal cancer patients diveated with single-agent cetuximab. J Clin Oncol. 2007 Aug 20;25(24):3712-8. [PubMed:17704420 ]

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