PI3KInhibitorpi3kinhibitor

Carvedilol

By

Carvedilol

Product: Taspoglutide

Identifier : DBSNPE000070
Drug : DB01136 (Carvedilol)
Interacting Gene/Enzyme : Beta-1 adrenergic receptor
Gene Name : ADRB1
UniProt ID : P08588
Defining Change(s) :

  • C Allele (rs1801253 )

Allele Name : Not Available
Genotype(s) : (C;C) / (C;G)
Type(s) : Effect Directly Studied
Groups : Not Available
Description : Improved response to blood pressure medication
References :

  1. Johnson JA, Zineh I, Puckett BJ, McGorray SP, Yarandi HN, Pauly DF: Beta 1-adrenergic receptor polymorphisms and antihypertensive response to metoprolol. Clin Pharmacol Ther. 2003 Jul;74(1):44-52. [PubMed:12844134 ]

PMID: 15531716

Carvedilol

By

Carvedilol

Product: NIH-12848

Identifier : DBSNPE000071
Drug : DB01136 (Carvedilol)
Interacting Gene/Enzyme : Beta-1 adrenergic receptor
Gene Name : ADRB1
UniProt ID : P08588
Defining Change(s) :

  • A Allele (rs1801252 )

Allele Name : Not Available
Genotype(s) : (A;A)
Type(s) : Effect Directly Studied
Groups : Not Available
Description : Improved response to blood pressure medication
References :

  1. Johnson JA, Zineh I, Puckett BJ, McGorray SP, Yarandi HN, Pauly DF: Beta 1-adrenergic receptor polymorphisms and antihypertensive response to metoprolol. Clin Pharmacol Ther. 2003 Jul;74(1):44-52. [PubMed:12844134 ]

PMID: 23349801

Carvedilol

By

Carvedilol

Product: Guanine

Identifier : DBSNPE000155
Drug : DB01136 (Carvedilol)
Interacting Gene/Enzyme : Beta-1 adrenergic receptor
Gene Name : ADRB1
UniProt ID : P08588
Defining Change(s) :

  • G > C (rs1801253 )

Allele Name : Not Available
Genotype(s) : (C;C) / (C;G)
Type(s) : Effect Directly Studied
Groups : Not Available
Description : Better response to drug therapy
References :

  1. Parvez B, Chopra N, Rowan S, Vaglio JC, Muhammad R, Roden DM, Darbar D: A common beta1-adrenergic receptor polymorphism predicts favorable response to rate-condivol therapy in adivial fibrillation. J Am Coll Cardiol. 2012 Jan 3;59(1):49-56. doi: 10.1016/j.jacc.2011.08.061. [PubMed:22192668 ]

PMID: 14691054

Carvedilol

By

Carvedilol

Product: Aztreonam

Identifier : DBSNPE004544
Drug : DB01136 (Carvedilol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • C allele (rs35742686 )

Allele Name : CYP2D6*3
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased dizziness.
References :

  1. Coreg® (carvedilol) tablets [package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2015. [Link]

PMID: 22570731

Carvedilol

By

Carvedilol

Product: Diphylline

Identifier : DBSNPE004545
Drug : DB01136 (Carvedilol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • C allele (rs3892097 )

Allele Name : CYP2D6*4
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased dizziness.
References :

  1. Coreg® (carvedilol) tablets [package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2015. [Link]

PMID: 21270292

Carvedilol

By

Carvedilol

Product: NBI-98854

Identifier : DBSNPE004546
Drug : DB01136 (Carvedilol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • Whole-gene deletion

Allele Name : CYP2D6*5
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased dizziness.
References :

  1. Coreg® (carvedilol) tablets [package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2015. [Link]

PMID: 22136135

Carvedilol

By

Carvedilol

Product: NBI-98782

Identifier : DBSNPE004547
Drug : DB01136 (Carvedilol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1707delT (rs5030655 )

Allele Name : CYP2D6*6
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased dizziness.
References :

  1. Coreg® (carvedilol) tablets [package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2015. [Link]

PMID: 20959451

Carvedilol

By

Carvedilol

Product: Betamethasone (hydrochloride)

Identifier : DBSNPE004548
Drug : DB01136 (Carvedilol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2935A>C (rs5030867 )

Allele Name : CYP2D6*7
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased dizziness.
References :

  1. Coreg® (carvedilol) tablets [package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2015. [Link]

PMID: 19176820

Carvedilol

By

Carvedilol

Product: Betamethasone

Identifier : DBSNPE004549
Drug : DB01136 (Carvedilol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1758G>T (rs5030865 )

Allele Name : CYP2D6*8
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased dizziness.
References :

  1. Coreg® (carvedilol) tablets [package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2015. [Link]

PMID: 17959795

Carvedilol

By

Carvedilol

Product: Iloperidone (hydrochloride)

Identifier : DBSNPE004550
Drug : DB01136 (Carvedilol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 883G>C (rs5030863 )

Allele Name : CYP2D6*11
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased dizziness.
References :

  1. Coreg® (carvedilol) tablets [package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2015. [Link]

PMID: 17671099

Carvedilol

By

Carvedilol

Product: Moxifloxacin

Identifier : DBSNPE004551
Drug : DB01136 (Carvedilol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 124G>A (rs5030862 )

Allele Name : CYP2D6*12
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased dizziness.
References :

  1. Coreg® (carvedilol) tablets [package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2015. [Link]

PMID: 17240481

Carvedilol

By

Carvedilol

Product: Marbofloxacin (hydrochloride)

Identifier : DBSNPE004552
Drug : DB01136 (Carvedilol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • CYP2D7/2D6 hybrid gene sdivucture

Allele Name : CYP2D6*13
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased dizziness.
References :

  1. Coreg® (carvedilol) tablets [package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2015. [Link]

PMID: 18573246

Carvedilol

By

Carvedilol

Product: Nocodazole

Identifier : DBSNPE004553
Drug : DB01136 (Carvedilol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1758G>A (rs5030865 )

Allele Name : CYP2D6*14A
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased dizziness.
References :

  1. Coreg® (carvedilol) tablets [package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2015. [Link]

PMID: 14723969

Carvedilol

By

Carvedilol

Product: Marbofloxacin

Identifier : DBSNPE004554
Drug : DB01136 (Carvedilol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 137insT, 137_138insT

Allele Name : CYP2D6*15
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased dizziness.
References :

  1. Coreg® (carvedilol) tablets [package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2015. [Link]

PMID: 16494499

Carvedilol

By

Carvedilol

Product: Ofloxacin

Identifier : DBSNPE004555
Drug : DB01136 (Carvedilol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2539_2542delAACT (rs72549353 )

Allele Name : CYP2D6*19
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased dizziness.
References :

  1. Coreg® (carvedilol) tablets [package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2015. [Link]

PMID: 14499282

Carvedilol

By

Carvedilol

Product: Atazanavir (sulfate)

Identifier : DBSNPE004556
Drug : DB01136 (Carvedilol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1973_1974insG (rs72549354 )

Allele Name : CYP2D6*20
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased dizziness.
References :

  1. Coreg® (carvedilol) tablets [package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2015. [Link]

PMID: 11334558

Carvedilol

By

Carvedilol

Product: Zonisamide (sodium)

Identifier : DBSNPE004557
Drug : DB01136 (Carvedilol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2573insC

Allele Name : CYP2D6*21
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased dizziness.
References :

  1. Coreg® (carvedilol) tablets [package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2015. [Link]

PMID: 10737674

Carvedilol

By

Carvedilol

Product: Zonisamide

Identifier : DBSNPE004558
Drug : DB01136 (Carvedilol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1770G>A
  • -1584C>G
  • -1235A>G
  • -740C>T
  • -678G>A
  • CYP2D7 gene conversion in indivon 1
  • 310G>T
  • 746C>G
  • 843T>G
  • 1661G>C
  • 2850C>T
  • 3384A>C
  • 3584G>A
  • 3790C>T
  • 4042G>A
  • 4180G>C
  • 4481G>A

Allele Name : CYP2D6*31
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased dizziness.
References :

  1. Coreg® (carvedilol) tablets [package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2015. [Link]

PMID: 9854049

Carvedilol

By

Carvedilol

Product: Ziprasidone (hydrochloride)

Identifier : DBSNPE004559
Drug : DB01136 (Carvedilol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 100C>T (rs1065852 )
  • -1426C>T
  • variable number of A’s in the region -1258 to -1237a
  • -1235A>G
  • -1000G>A
  • 1039C>T
  • 1661G>C
  • gene conversion to CYP2D7 in exon 9
  • 4180G>C

Allele Name : CYP2D6*36
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased dizziness.
References :

  1. Coreg® (carvedilol) tablets [package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2015. [Link]

PMID: 21680731

Carvedilol

By

Carvedilol

Product: Topiramate

Identifier : DBSNPE004560
Drug : DB01136 (Carvedilol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2587_2590delGACT (rs72549351 )

Allele Name : CYP2D6*38
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased dizziness.
References :

  1. Coreg® (carvedilol) tablets [package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2015. [Link]

PMID: 22607676

Carvedilol

By

Carvedilol

Product: Sumatriptan (succinate)

Identifier : DBSNPE004561
Drug : DB01136 (Carvedilol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1863_1864ins(TTT CGC CCC)2 (rs72549356 )

Allele Name : CYP2D6*40
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased dizziness.
References :

  1. Coreg® (carvedilol) tablets [package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2015. [Link]

PMID: 15582717

Carvedilol

By

Carvedilol

Product: Risedronate (sodium)

Identifier : DBSNPE004562
Drug : DB01136 (Carvedilol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 3259_3260insGT (rs72549346 )

Allele Name : CYP2D6*42
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased dizziness.
References :

  1. Coreg® (carvedilol) tablets [package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2015. [Link]

PMID: 12047910

Carvedilol

By

Carvedilol

Product: Clopidogrel (hydrogen sulfate)

Identifier : DBSNPE004563
Drug : DB01136 (Carvedilol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2950G>C

Allele Name : CYP2D6*44
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased dizziness.
References :

  1. Coreg® (carvedilol) tablets [package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2015. [Link]

PMID: 14617685

Carvedilol

By

Carvedilol

Product: Vecuronium (bromide)

Identifier : DBSNPE004564
Drug : DB01136 (Carvedilol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 100C>T (rs1065852 )
  • -1426C>T
  • -1235A>G
  • -1000G>A
  • 73C<T
  • 1039C>T
  • 1661G>C
  • 4180G>C

Allele Name : CYP2D6*47
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased dizziness.
References :

  1. Coreg® (carvedilol) tablets [package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2015. [Link]

PMID: 14980673

Carvedilol

By

Carvedilol

Product: SB 203580 (hydrochloride)

Identifier : DBSNPE004565
Drug : DB01136 (Carvedilol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1584C>G
  • -1235A>G
  • -740C>T
  • -678G>A
  • CYP2D7 gene conversion in indivon 1
  • 1661G>C
  • 2850C>T
  • 3172A>C
  • 4180G>C

Allele Name : CYP2D6*51
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased dizziness.
References :

  1. Coreg® (carvedilol) tablets [package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2015. [Link]

PMID: 17105869

Carvedilol

By

Carvedilol

Product: Embelin

Identifier : DBSNPE004566
Drug : DB01136 (Carvedilol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 3201C>T (rs72549347 )

Allele Name : CYP2D6*56
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased dizziness.
References :

  1. Coreg® (carvedilol) tablets [package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2015. [Link]

PMID: 16377459

Carvedilol

By

Carvedilol

Product: DL-threo-2-methylisocitrate

Identifier : DBSNPE004567
Drug : DB01136 (Carvedilol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 100C>T
  • 310G>T
  • 843T>G
  • 887C>T
  • 1039C>T
  • 1661G>C
  • 3384A>C
  • 3582A>G
  • gene conversion to CYP2D7 in exon 9
  • 4180G>C

Allele Name : CYP2D6*57
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased dizziness.
References :

  1. Coreg® (carvedilol) tablets [package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2015. [Link]

PMID: 10872822

Carvedilol

By

Carvedilol

Product: Zileuton (sodium)

Identifier : DBSNPE004568
Drug : DB01136 (Carvedilol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 4044C>T

Allele Name : CYP2D6*62
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased dizziness.
References :

  1. Coreg® (carvedilol) tablets [package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2015. [Link]

PMID: 25993471

Carvedilol

By

Carvedilol

Product: Tigecycline (mesylate)

Identifier : DBSNPE004569
Drug : DB01136 (Carvedilol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1426C>T
  • -1235A>G
  • -1000G>A
  • 100C>T
  • 310G>T
  • CYP2D7 sequence from indivon 1 onwards

Allele Name : CYP2D6*68A
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased dizziness.
References :

  1. Coreg® (carvedilol) tablets [package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2015. [Link]

PMID: 19098165

Carvedilol

By

Carvedilol

Product: Tigecycline (hydrochloride)

Identifier : DBSNPE004570
Drug : DB01136 (Carvedilol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • Similar but not identical switch region compared to CYP2D6*68A. Found in tandem arrangement with CYP2D6*4.

Allele Name : CYP2D6*68B
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased dizziness.
References :

  1. Coreg® (carvedilol) tablets [package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2015. [Link]

PMID: 17331209

Carvedilol

By

Carvedilol

Product: Tigecycline

Identifier : DBSNPE004571
Drug : DB01136 (Carvedilol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2988G>A (rs28371725 )
  • -1426C>T
  • -1235A>G
  • -1000G>A
  • 100C>T
  • 310G>T
  • 746C>G
  • 843T>G
  • 1062A>G
  • 1661G>C
  • 2850C>T
  • 3384A>C
  • 3584G>A
  • 3790C>T
  • 4180G>C
  • 4401C>T
  • 4481G>A

Allele Name : CYP2D6*69
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased dizziness.
References :

  1. Coreg® (carvedilol) tablets [package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2015. [Link]

PMID: 12139462

Carvedilol

By

Carvedilol

Product: Tenofovir (maleate)

Identifier : DBSNPE004572
Drug : DB01136 (Carvedilol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1995delC

Allele Name : CYP2D6*92
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased dizziness.
References :

  1. Coreg® (carvedilol) tablets [package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2015. [Link]

PMID: 12145156

Carvedilol

By

Carvedilol

Product: Tenofovir (hydrate)

Identifier : DBSNPE004573
Drug : DB01136 (Carvedilol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1426C>T
  • -1235A>G
  • -1109C>T
  • -1000G>A
  • 100C>T
  • 310G>T
  • 843T>G
  • 1039C>T
  • 1661G>C
  • 2097A>G
  • 2828delC
  • 3384A>C
  • 3582A>G
  • 4180G>C
  • 4401C>T

Allele Name : CYP2D6*100
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased dizziness.
References :

  1. Coreg® (carvedilol) tablets [package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2015. [Link]

PMID: 26131716

Carvedilol

By

Carvedilol

Product: Stavudine (sodium)

Identifier : DBSNPE004574
Drug : DB01136 (Carvedilol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1426C>T
  • -1235A>G
  • -1000G>A
  • 100C>T
  • 310G>T
  • 843T>G
  • 1039C>T
  • 1661G>C
  • 2097A>G
  • 2927_2945delGATCCTACATCCGGATGTG
  • 3384A>C
  • 3582A>G
  • 4180G>C
  • 4401C>T

Allele Name : CYP2D6*101
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased dizziness.
References :

  1. Coreg® (carvedilol) tablets [package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2015. [Link]

PMID: 12067557

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