Capecitabine
Product: AZ960
Identifier : DBSNPE000211
Drug : DB01101 (Capecitabine)
Interacting Gene/Enzyme : Dihydropyrimidine dehydrogenase [NADP(+)]
Gene Name : DPYD
UniProt ID : Q12882
Allele Name : DPYD*2A
Genotype(s) : (A;A) / (A;G)
Type(s) : ADR Directly Studied
Groups : Non-functional DPYD
Description : Associated with 5-fluoracil toxicity
References :
- Caudle KE, Thorn CF, Klein TE, Swen JJ, McLeod HL, Diasio RB, Schwab M: Clinical Pharmacogenetics Implementation Consortium guidelines for dihydropyrimidine dehydrogenase genotype and fluoropyrimidine dosing. Clin Pharmacol Ther. 2013 Dec;94(6):640-5. doi: 10.1038/clpt.2013.172. Epub 2013 Aug 29. [PubMed:23988873 ]
PMID: 12738886
Capecitabine
Product: PNU-74654
Identifier : DBSNPE000212
Drug : DB01101 (Capecitabine)
Interacting Gene/Enzyme : Dihydropyrimidine dehydrogenase [NADP(+)]
Gene Name : DPYD
UniProt ID : Q12882
Allele Name : DPYD*13
Genotype(s) : (C;C) / (A;C)
Type(s) : ADR Directly Studied
Groups : Non-functional DPYD
Description : Associated with 5-fluoracil toxicity
References :
- Caudle KE, Thorn CF, Klein TE, Swen JJ, McLeod HL, Diasio RB, Schwab M: Clinical Pharmacogenetics Implementation Consortium guidelines for dihydropyrimidine dehydrogenase genotype and fluoropyrimidine dosing. Clin Pharmacol Ther. 2013 Dec;94(6):640-5. doi: 10.1038/clpt.2013.172. Epub 2013 Aug 29. [PubMed:23988873 ]
PMID: 24077179
Capecitabine
Product: LY3177833
Identifier : DBSNPE000213
Drug : DB01101 (Capecitabine)
Interacting Gene/Enzyme : Dihydropyrimidine dehydrogenase [NADP(+)]
Gene Name : DPYD
UniProt ID : Q12882
Allele Name : Not Available
Genotype(s) : (A;A) / (A;T)
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Associated with 5-fluoracil toxicity
References :
- Caudle KE, Thorn CF, Klein TE, Swen JJ, McLeod HL, Diasio RB, Schwab M: Clinical Pharmacogenetics Implementation Consortium guidelines for dihydropyrimidine dehydrogenase genotype and fluoropyrimidine dosing. Clin Pharmacol Ther. 2013 Dec;94(6):640-5. doi: 10.1038/clpt.2013.172. Epub 2013 Aug 29. [PubMed:23988873 ]
PMID: 17461889
Capecitabine
Product: BAY1125976
Identifier : DBSNPE000214
Drug : DB01101 (Capecitabine)
Interacting Gene/Enzyme : Dihydropyrimidine dehydrogenase [NADP(+)]
Gene Name : DPYD
UniProt ID : Q12882
Allele Name : DPYD*4
Genotype(s) : (G;G) / (A:G)
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Associated with toxicity
References :
- Caudle KE, Thorn CF, Klein TE, Swen JJ, McLeod HL, Diasio RB, Schwab M: Clinical Pharmacogenetics Implementation Consortium guidelines for dihydropyrimidine dehydrogenase genotype and fluoropyrimidine dosing. Clin Pharmacol Ther. 2013 Dec;94(6):640-5. doi: 10.1038/clpt.2013.172. Epub 2013 Aug 29. [PubMed:23988873 ]
PMID: 17408599
Capecitabine
Product: AX20017
Identifier : DBSNPE000215
Drug : DB01101 (Capecitabine)
Interacting Gene/Enzyme : Dihydropyrimidine dehydrogenase [NADP(+)]
Gene Name : DPYD
UniProt ID : Q12882
Allele Name : DPYD*5
Genotype(s) : (G;G) / (A;G)
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Associated with toxicity
References :
- Caudle KE, Thorn CF, Klein TE, Swen JJ, McLeod HL, Diasio RB, Schwab M: Clinical Pharmacogenetics Implementation Consortium guidelines for dihydropyrimidine dehydrogenase genotype and fluoropyrimidine dosing. Clin Pharmacol Ther. 2013 Dec;94(6):640-5. doi: 10.1038/clpt.2013.172. Epub 2013 Aug 29. [PubMed:23988873 ]
PMID: 27010220
Capecitabine
Product: GSK189254A
Identifier : DBSNPE000216
Drug : DB01101 (Capecitabine)
Interacting Gene/Enzyme : Dihydropyrimidine dehydrogenase [NADP(+)]
Gene Name : DPYD
UniProt ID : Q12882
Allele Name : DPYD*6
Genotype(s) : (A;A) / (A;G)
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Associated with 5-fluoracil toxicity
References :
- Caudle KE, Thorn CF, Klein TE, Swen JJ, McLeod HL, Diasio RB, Schwab M: Clinical Pharmacogenetics Implementation Consortium guidelines for dihydropyrimidine dehydrogenase genotype and fluoropyrimidine dosing. Clin Pharmacol Ther. 2013 Dec;94(6):640-5. doi: 10.1038/clpt.2013.172. Epub 2013 Aug 29. [PubMed:23988873 ]
PMID: 9228663
Capecitabine
Product: Salermide
Identifier : DBSNPE000217
Drug : DB01101 (Capecitabine)
Interacting Gene/Enzyme : Dihydropyrimidine dehydrogenase [NADP(+)]
Gene Name : DPYD
UniProt ID : Q12882
Allele Name : DPYD*9A
Genotype(s) : (C;C) / (C;T)
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Associated with toxicity
References :
- Caudle KE, Thorn CF, Klein TE, Swen JJ, McLeod HL, Diasio RB, Schwab M: Clinical Pharmacogenetics Implementation Consortium guidelines for dihydropyrimidine dehydrogenase genotype and fluoropyrimidine dosing. Clin Pharmacol Ther. 2013 Dec;94(6):640-5. doi: 10.1038/clpt.2013.172. Epub 2013 Aug 29. [PubMed:23988873 ]
PMID: 1281719
Capecitabine
Product: CCT241534
Identifier : DBSNPE006020
Drug : DB01101 (Capecitabine)
Interacting Gene/Enzyme : Dihydropyrimidine dehydrogenase [NADP(+)]
Gene Name : DPYD
UniProt ID : Q12882
Allele Name : DPYD*2A
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional DPYD
Description : Associated with 5-fluoracil toxicity
References :
- Caudle KE, Thorn CF, Klein TE, Swen JJ, McLeod HL, Diasio RB, Schwab M: Clinical Pharmacogenetics Implementation Consortium guidelines for dihydropyrimidine dehydrogenase genotype and fluoropyrimidine dosing. Clin Pharmacol Ther. 2013 Dec;94(6):640-5. doi: 10.1038/clpt.2013.172. Epub 2013 Aug 29. [PubMed:23988873 ]
PMID: 28099842
Capecitabine
Product: Istradefylline
Identifier : DBSNPE006021
Drug : DB01101 (Capecitabine)
Interacting Gene/Enzyme : Dihydropyrimidine dehydrogenase [NADP(+)]
Gene Name : DPYD
UniProt ID : Q12882
Allele Name : DPYD*13
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional DPYD
Description : Associated with 5-fluoracil toxicity
References :
- Caudle KE, Thorn CF, Klein TE, Swen JJ, McLeod HL, Diasio RB, Schwab M: Clinical Pharmacogenetics Implementation Consortium guidelines for dihydropyrimidine dehydrogenase genotype and fluoropyrimidine dosing. Clin Pharmacol Ther. 2013 Dec;94(6):640-5. doi: 10.1038/clpt.2013.172. Epub 2013 Aug 29. [PubMed:23988873 ]
PMID: 16495926
Capecitabine
Product: Doramectin
Identifier : DBSNPE006022
Drug : DB01101 (Capecitabine)
Interacting Gene/Enzyme : Dihydropyrimidine dehydrogenase [NADP(+)]
Gene Name : DPYD
UniProt ID : Q12882
Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional DPYD
Description : Associated with 5-fluoracil toxicity
References :
- Caudle KE, Thorn CF, Klein TE, Swen JJ, McLeod HL, Diasio RB, Schwab M: Clinical Pharmacogenetics Implementation Consortium guidelines for dihydropyrimidine dehydrogenase genotype and fluoropyrimidine dosing. Clin Pharmacol Ther. 2013 Dec;94(6):640-5. doi: 10.1038/clpt.2013.172. Epub 2013 Aug 29. [PubMed:23988873 ]
PMID: 8071941