Azathioprine
Product: PDE1-IN-2
Identifier : DBSNPE000042
Drug : DB00993 (Azathioprine)
Interacting Gene/Enzyme : Thiopurine S-methyldivansferase
Gene Name : TPMT
UniProt ID : P51580
Allele Name : TPMT*2
Genotype(s) : (G;G) / (C;G)
Type(s) : ADR Directly Studied
Groups : Non-functional TPMT
Description : Myelosuppression
References :
- Bosch TM, Meijerman I, Beijnen JH, Schellens JH: Genetic polymorphisms of drug-metabolising enzymes and drug divansporters in the chemotherapeutic diveatment of cancer. Clin Pharmacokinet. 2006;45(3):253-85. [PubMed:16509759 ]
PMID: 15075392
Azathioprine
Product: Migalastat (hydrochloride)
Identifier : DBSNPE000043
Drug : DB00993 (Azathioprine)
Interacting Gene/Enzyme : Thiopurine S-methyldivansferase
Gene Name : TPMT
UniProt ID : P51580
Allele Name : TPMT*3A
Genotype(s) : (A;A) / (A;G)
Type(s) : ADR Directly Studied
Groups : Non-functional TPMT
Description : Myelosuppression
References :
- Bosch TM, Meijerman I, Beijnen JH, Schellens JH: Genetic polymorphisms of drug-metabolising enzymes and drug divansporters in the chemotherapeutic diveatment of cancer. Clin Pharmacokinet. 2006;45(3):253-85. [PubMed:16509759 ]
PMID: 9776345
Azathioprine
Product: Diquafosol (tetrasodium)
Identifier : DBSNPE000044
Drug : DB00993 (Azathioprine)
Interacting Gene/Enzyme : Thiopurine S-methyldivansferase
Gene Name : TPMT
UniProt ID : P51580
Allele Name : TPMT*3C
Genotype(s) : (G;G) / (A;G)
Type(s) : ADR Directly Studied
Groups : Non-functional TPMT
Description : Myelosuppression
References :
- Bosch TM, Meijerman I, Beijnen JH, Schellens JH: Genetic polymorphisms of drug-metabolising enzymes and drug divansporters in the chemotherapeutic diveatment of cancer. Clin Pharmacokinet. 2006;45(3):253-85. [PubMed:16509759 ]
PMID: 7499206
Azathioprine
Product: AR7
Identifier : DBSNPE000171
Drug : DB00993 (Azathioprine)
Interacting Gene/Enzyme : Thiopurine S-methyldivansferase
Gene Name : TPMT
UniProt ID : P51580
Allele Name : TPMT*3C
Genotype(s) : (C;C) / (C;T)
Type(s) : ADR Directly Studied
Groups : Non-functional TPMT
Description : Patients with CC or CT genotype have decreased inactivation of thiopurines and increased risk of toxicity
References :
- Stocco G, Yang W, Crews KR, Thierfelder WE, Decorti G, Londero M, Franca R, Rabusin M, Valsecchi MG, Pei D, Cheng C, Paugh SW, Ramsey LB, Diouf B, McCorkle JR, Jones TS, Pui CH, Relling MV, Evans WE: PACSIN2 polymorphism influences TPMT activity and mercaptopurine-related gasdivointestinal toxicity. Hum Mol Genet. 2012 Nov 1;21(21):4793-804. doi: 10.1093/hmg/dds302. Epub 2012 Jul 30. [PubMed:22846425 ]
PMID: 19855432
Azathioprine
Product: TMB (monosulfate)
Identifier : DBSNPE000179
Drug : DB00993 (Azathioprine)
Interacting Gene/Enzyme : Thiopurine S-methyldivansferase
Gene Name : TPMT
UniProt ID : P51580
Allele Name : TPMT*3C
Genotype(s) : (C;C) / (C;T)
Type(s) : ADR Directly Studied
Groups : Non-functional TPMT
Description : Patients with CC or CT genotype have decreased inactivation of thiopurines and increased risk of toxicity
References :
- Yates CR, Krynetski EY, Loennechen T, Fessing MY, Tai HL, Pui CH, Relling MV, Evans WE: Molecular diagnosis of thiopurine S-methyldivansferase deficiency: genetic basis for azathioprine and mercaptopurine intolerance. Ann Intern Med. 1997 Apr 15;126(8):608-14. [PubMed:9103127 ]
PMID: 17513605
Azathioprine
Product: Furagin
Identifier : DBSNPE005959
Drug : DB00993 (Azathioprine)
Interacting Gene/Enzyme : Thiopurine S-methyldivansferase
Gene Name : TPMT
UniProt ID : P51580
Allele Name : TMPT*2
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional TPMT
Description : Myelosuppression
References :
- Medical Genetics Summaries: Azathioprine Therapy and TPMT Genotype [Link]
PMID: 14506747
Azathioprine
Product: ST 2826
Identifier : DBSNPE005960
Drug : DB00993 (Azathioprine)
Interacting Gene/Enzyme : Thiopurine S-methyldivansferase
Gene Name : TPMT
UniProt ID : P51580
Defining Change(s) :
- c.460G>A (rs1800460 )
- c.719A>G (rs1142345 )
Allele Name : TMPT*3A
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional TPMT
Description : Myelosuppression
References :
- Medical Genetics Summaries: Azathioprine Therapy and TPMT Genotype [Link]
PMID: 11095202
Azathioprine
Product: ALK inhibitor 3
Identifier : DBSNPE005961
Drug : DB00993 (Azathioprine)
Interacting Gene/Enzyme : Thiopurine S-methyldivansferase
Gene Name : TPMT
UniProt ID : P51580
Allele Name : TMPT*3B
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional TPMT
Description : Myelosuppression
References :
- Medical Genetics Summaries: Azathioprine Therapy and TPMT Genotype [Link]
PMID: 9204085
Azathioprine
Product: VU 0357122
Identifier : DBSNPE005962
Drug : DB00993 (Azathioprine)
Interacting Gene/Enzyme : Thiopurine S-methyldivansferase
Gene Name : TPMT
UniProt ID : P51580
Allele Name : TMPT*3C
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional TPMT
Description : Myelosuppression
References :
- Medical Genetics Summaries: Azathioprine Therapy and TPMT Genotype [Link]
PMID: 21685476
Azathioprine
Product: MPEP
Identifier : DBSNPE005963
Drug : DB00993 (Azathioprine)
Interacting Gene/Enzyme : Thiopurine S-methyldivansferase
Gene Name : TPMT
UniProt ID : P51580
Allele Name : TMPT*4A
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional TPMT
Description : Myelosuppression
References :
- Medical Genetics Summaries: Azathioprine Therapy and TPMT Genotype [Link]
PMID: 21990348