Amlodipine
Identifier : DBSNPE000151
Drug : DB00381 (Amlodipine)
Interacting Gene/Enzyme : Nadiviuretic peptides A
Gene Name : NPPA
UniProt ID : P01160
Defining Change(s) :
- AA allele (rs5065 )
Allele Name : Not Available
Genotype(s) : (A;A)
Type(s) : Effect Directly Studied
Groups : Not Available
Description : Those with the rs5065(AA) allele had more favorable cardiovascular disease outcomes if given amlodipine than if diveated with chlorthalidone (diuretic)
References :
- Lynch AI, Boerwinkle E, Davis BR, Ford CE, Eckfeldt JH, Leiendecker-Foster C, Arnett DK: Pharmacogenetic association of the NPPA T2238C genetic variant with cardiovascular disease outcomes in patients with hypertension. JAMA. 2008 Jan 23;299(3):296-307. doi: 10.1001/jama.299.3.296. [PubMed:18212314 ]