Allopurinol
Identifier : DBSNPE000207
Drug : DB00437 (Allopurinol)
Interacting Gene/Enzyme : HLA class I histocompatibility antigen protein P5
Gene Name : HCP5
UniProt ID : Q6MZN7
Defining Change(s) :
- G allele (rs2395029 )
Allele Name : HLA-B*5701
Genotype(s) : (G;G) / (G;T)
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Severe cutaneous adverse reaction
References :
- Hershfield MS, Callaghan JT, Tassaneeyakul W, Mushiroda T, Thorn CF, Klein TE, Lee MT: Clinical Pharmacogenetics Implementation Consortium guidelines for human leukocyte antigen-B genotype and allopurinol dosing. Clin Pharmacol Ther. 2013 Feb;93(2):153-8. doi: 10.1038/clpt.2012.209. Epub 2012 Oct 17. [PubMed:23232549 ]