Afatinib
Identifier : DBSNPE000164
Drug : DB08916 (Afatinib)
Interacting Gene/Enzyme : Epidermal growth factor receptor
Gene Name : EGFR
UniProt ID : P00533
Defining Change(s) :
- T > A or G (rs121913444 )
Allele Name : L861Q
Genotype(s) : (A;A) / (A;T) / (G;G) / (G;T)
Type(s) : Effect Directly Studied
Groups : Not Available
Description : Associated with enhanced activation of the EGFR tyrosine kinase in patients with non-small cell lung cancer (NSCLC) recieving tyrosine kinase inhibitor therapy.
References :
- Lynch TJ, Bell DW, Sordella R, Gurubhagavatula S, Okimoto RA, Brannigan BW, Harris PL, Haserlat SM, Supko JG, Haluska FG, Louis DN, Christiani DC, Settleman J, Haber DA: Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med. 2004 May 20;350(21):2129-39. Epub 2004 Apr 29. [PubMed:15118073 ]