Abciximab
Identifier : DBSNPE000134
Drug : DB00054 (Abciximab)
Interacting Gene/Enzyme : Integrin beta-3
Gene Name : ITGB3
UniProt ID : P05106
Defining Change(s) :
- A2 Allele (rs5918 )
Allele Name : GPIIIa PlA2
Genotype(s) : (C;C) / (C;T)
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Associated with greater restenosis and risk for subacute coronary thrombosis in patients administered antiplatelet therapy.
References :
- Neumann FJ, Kasdivati A, Schmitt C, Blasini R, Hadamitzky M, Mehilli J, Gawaz M, Schleef M, Seyfarth M, Dirschinger J, Schomig A: Effect of glycoprotein IIb/IIIa receptor blockade with abciximab on clinical and angiographic restenosis rate after the placement of coronary stents following acute myocardial infarction. J Am Coll Cardiol. 2000 Mar 15;35(4):915-21. [PubMed:10732888 ]