DNMT3L operates by advertising the rearrangement of large DNMT3A2 complexes into described hetero-dimeric sub-complexes with enhanced catalytic likely, increased affinity for SAM, and increased processivity
Taken collectively, our info demonstrates that inactive DNMT3B variants can take part in mixed cocomplexes with energetic DNMT3 enzymes, but that their method of interactions are distinctive from people explained…